Research
My research sits at the intersection of genomics, clinical data science, and global health. Over the course of my career I have worked on problems ranging from population-level genetic variation to practical machine learning for healthcare delivery in low-resource settings.
Current: Neotree
As Senior Data Scientist at UCL, I work on the Neotree project — a digital health system designed to improve neonatal outcomes in sub-Saharan Africa. Neotree captures structured clinical data at the bedside and uses that data to drive quality improvement and clinical decision support.
My work within Neotree focuses on:
- Developing and validating machine learning models for neonatal diagnosis and triage
- Optimising clinical decision support algorithms for deployment in low-connectivity environments
- Assessing model performance and fairness across different hospital settings and populations
- Building reproducible analysis pipelines for ongoing data quality monitoring
Population genetics & genomics
Earlier in my career I focused on the genetics of complex traits and the genomic diversity of human populations. This work spanned molecular diagnostics, genome-wide association studies, and the statistical methodology needed to make sense of high-dimensional genetic data.
Key themes included:
- Population structure and admixture in European and Latin American cohorts
- Genetic epidemiology of complex diseases
- Development of molecular diagnostic assays and their validation
One Health & environmental genomics
I am interested in the One Health framework — the recognition that human health, animal health, and environmental health are inextricably linked. Data science has a critical role to play in integrating these streams, and I am exploring opportunities to apply genomic and epidemiological methods across this wider health landscape.
Publications & profiles
For a full list of publications, citations, and research metrics, please visit my profiles:
- ORCID: orcid.org/0000-0003-2042-0961
- UCL Research Profile: profiles.ucl.ac.uk/99221-david-de-lorenzo
Collaborations
I welcome enquiries about research collaborations, particularly in the areas of clinical AI, global health data, and genomic epidemiology. Please see the contact section or write to me directly.